A small group of Nicaraguans demonstrated against Ortega outside the presidential palace in San José, where Pompeo had talks with Costa Rican President Carlos Alvarado.
The head of US diplomacy, Mike Pompeo, will meet on Monday in Colombia with the Venezuelan opposition leader Juan Guaidó, on his first stop of a three-day trip to Latin America and the Caribbean.
Many international observers say the country -- with 60 percent poverty -- is in no shape to welcome refugees but simply signed the agreement under intense US pressure.